Capacity:forupto1×109totalcellsOverview
TheAnti-ABCG2(CD338)MicroBeadshavebeendevelopedforthepositiveselectionofABCG2+(CD338)cells,alsoreferredasSidePopulationcells(SP),inasinglestep.SPcellscanbeisolatedfromvarioussourcessuchasbonemarroworcordblood.
Details
Backgroundinformation
ABCG2,alsoknownasCD338orBCRP1,isamulti-drugresistance(MDR)familyproteinthatisamemberofATP-bindingcassette(ABC)transporters.ABCproteinstransportvariousmoleculesacrossextracellularandintracellularmembranes.Itfunctionsasaxenobiotictransporterwhichmayplayaroleinmulti-drugresistancetochemotherapeuticagents1.ABCG2ishighlyexpressedonprimitivesidepopulation(SP)stemcells.ThisSPphenotypeisbasedontheeffluxoffluorescentdyessuchasRhodamine123andHoechst33342byABCG2.ItwasshownthatexpressionoftheABCG2geneisaconservedfeatureofstemcellsfromawidevarietyofsources.
Columns
Forpositiveselection:MS,LS,XS,orauto
MACS®Columns.Fordepletion:LD,CS,D,orautoMACSColumns.