LysophosphatidicAcid(LPA)isaserum-derivedphospholipidinvolvedindiversecellularprocessessuchascellproliferation,chemotaxis,plateletaggregation,woundhealing,angiogenesis,tumorinvasion,andsmoothmusclecontraction.RecentresearchindicatesLPAmayplayasignificantroleinthepathophysiologyofcancerandmaybeusedasabioMarkerforovariancancer.(SeveralliteraturecitationsindicateplasmaLPAlevelsareelevatedinovariancancerpatients). LPAisquantifiedusingEchelon’sLPAELISAIIcatalog#K-2800s(seeK-2800sTDSformoreinformation).TheLPAELISAIIisasensitiveandrobustmethodforquantificationofserumLPAina96-wellplatecompetitiveELISAformat.Aslittleas50μLofsampleissufficientforduplicatedatapoints.Eachsamplewillberuninduplicateunlessindicatedbythecustomertodootherwise.Thedatawillbeprovidedasanaverageoftheduplicatedatapoints.TheLPAAssayKitwasco-developedusingtheproprietarymonoclonalantibodyofLpathInc.(SanDiego,CA.www.lpath.com).
Pleaserefertothetechnicaldatasheetforsampleconsiderationsandshippinginformation.ToplaceanorderpleasecontactEchelonat801.588.0455.
Disclaimer:Lpath,Inc.hasanumberofpatentapplicationspendingorissuedcoveringmaterial(s)incorporatedintothisassay.Theassay`sintendeduseisforthemeasurementofLPAinbiologicalsamples.Anyotheruse,includingdrugdiscovery,requiresalicensefromLpath(www.lpath.com). |