CatalogNo.: S-100T MW: 727.95
Description: Echelonoffersauniqueselectionofsphingosineanalogslabeledattheterminusofthealkylchainwithbiotinorfluorescentgroups.Allcompoundsaresynthesizedfromchiralprecursorsandareavailableaslyophilizedpowders. Echelon'salkyl-labeledsphingosinesaresynthesizedwiththenaturalerythrostereochemistryandmaintainsimilarpropertiesassphingosine.Forexample,labeledsphingosinesarephosphorylatedbysphingosinekinases(1&2)andcanbeusedinhighthroughputscreeningapplications.Inaddition,theyinduceaNiemanPicktypeC1diseasecellularphenoypeinRAWmacrophagesinthesamemannerasexogenouslyaddedsphingosine. |