Recombinant rabbit monoclonal antibody raised against human ABCB1.
Immunogen:
Original antibody is raised against drug resistant K-562 cells.
Reactivity:
Human
Specificity:
This antibody recognizes a discontinuous extracellular epitope on ABCB1.
Form:
Liquid
Purification:
Protein A affinity purification
Isotype:
IgG, kappa
Recommend Usage:
Flow Cytometry (1 ug/mL)ImmunofluorescenceImmunoprecipitation (10 ug/mL)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, pH 7.2 (0.02% Proclin 300).
Storage Instruction:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Antibody Species:
Rabbit
Datasheet:
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Applications
Immunofluorescence
Immunoprecipitation
Flow Cytometry
Application Image
Immunofluorescence
Immunoprecipitation
Flow Cytometry
Gene Information
Entrez GeneID:
5243
Protein Accession#:
P08183
Gene Name:
ABCB1
Gene Alias:
ABC20,CD243,CLCS,GP170,MDR1,MGC163296,P-GP,PGY1
Gene Description:
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Omim ID:
171050
Gene Ontology:
Hyperlink
Gene Summary:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
Other Designations:
ATP-binding cassette, subfamily B, member 1,P glycoprotein 1,P-glycoprotein 1,colchicin sensitivity,doxorubicin resistance,multidrug resistance 1,multidrug resistance protein 1
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