Rabbit polyclonal antibody raised against synthetic phosphopeptide of ADRB2.
Immunogen:
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S261 of human ADRB2.
Host:
Rabbit
Reactivity:
Human
Form:
Liquid
Purification:
Protein A purification
Recommend Usage:
ELISA (1:1000)Dot Blot (1:500)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS (0.09% sodium azide)
Storage Instruction:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Publication Reference
1.
Association between a beta2-adrenergic receptor polymorphism and elite endurance performance.Wolfarth B, Rankinen T, Muhlbauer S, Scherr J, Boulay MR, Perusse L, Rauramaa R, Bouchard C.Metabolism. 2007 Dec;56(12):1649-51.
2.
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25.
Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of ADRB2 (phospho S261) polyclonal antibody (Cat # PAB8156) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL.
Application Image
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
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Gene Information
Entrez GeneID:
154
Protein Accession#:
P07550;NP_000015
Gene Name:
ADRB2
Gene Alias:
ADRB2R,ADRBR,B2AR,BAR,BETA2AR
Gene Description:
adrenergic, beta-2-, receptor, surface
Omim ID:
109690, 600807, 601665
Gene Ontology:
Hyperlink
Gene Summary:
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq
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