Rabbit polyclonal antibody raised against synthetic phosphopeptide of ABL1.
Immunogen:
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y393 of human ABL1.
Host:
Rabbit
Reactivity:
Human
Form:
Liquid
Purification:
Protein A purification
Recommend Usage:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)Dot Blot (1:100-500)Western Blot (1:1000)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS (0.09% sodium azide)
Storage Instruction:
Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of A2058 cell line lysate with ABL1 (phospho Y393) polyclonal antibody (Cat # PAB30835).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human breast carcinoma with ABL1 (phospho Y393) polyclonal antibody (Cat # PAB30835), followed by peroxidase-conjugated secondary antibody and AEC staining.
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
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