Rabbit polyclonal antibody raised against synthetic peptide of CD244.
Immunogen:
A synthetic peptide corresponding to 16 amino acids near C-terminus of human CD244.
Sequence:
PKAQNPARLSRKELEN
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
Specificity:
At least three isoforms of CD244 are known to exist. This antibody is predicted to not cross-react with other SLAM protein family members.
Form:
Liquid
Purification:
Peptide affinity purification
Concentration:
1 mg/mL
Recommend Usage:
Western Blot (1-2 ug/mL)Immunofluorescence (20 ug/mL)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS (0.02% sodium azide)
Storage Instruction:
Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Applications
Western Blot (Cell lysate)
Western blot analysis of CD244 in Daudi cell lysate with CD244 polyclonal antibody (Cat # PAB19379) at (1) 1 and (2) 2 ug/mL.
Immunofluorescence
Immunofluorescencent staining of Daudi cells with CD244 polyclonal antibody (Cat # PAB19379) at 20 ug/mL.
Enzyme-linked Immunoabsorbent Assay
Application Image
Western Blot (Cell lysate)
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Immunofluorescence
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Enzyme-linked Immunoabsorbent Assay
Gene Information
Entrez GeneID:
51744
Protein Accession#:
NP_1160135
Gene Name:
CD244
Gene Alias:
2B4,NAIL,NKR2B4,Nmrk,SLAMF4
Gene Description:
CD244 molecule, natural killer cell receptor 2B4
Omim ID:
605554
Gene Ontology:
Hyperlink
Gene Summary:
Natural killer (NK) cells express both activating and inhibitory cell surface receptors. Inhibitory signaling receptors all possess cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, or ITIMs, whereas the activating receptors lack ITIMs and associate with DAP12 (TYROBP; MIM 604142), which contains an immunoreceptor tyrosine-based activation motif, or ITAM. Killer cell immunoglobulin (Ig)-like receptors, or KIRs (see KIR2DL1; MIM 604936), and other NK cell receptors interact with major histocompatibility complex (MHC) molecules (see MIM 142800). Members of the CD2 (MIM 186990) family adhere to each other instead. The cell surface glycoprotein 2B4 is related to CD2 and is implicated in the regulation of NK- and T-cell function (Boles et al., 1999 [PubMed 10458320]).[supplied by OMIM
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