Lyophilized from 50 mM phosphate buffer, 100 mM NaCl, 500 ug glycine, pH 7.4
Storage Instruction:
Store at -80°C.After reconstitution with deionized water, store at -80°C.Aliquot to avoid repeated freezing and thawing.
Note:
Do not use alpha-2-Macroglobulin in presence of DTT, even at 1 mM DTT causes reversible dissociation into inactive subunits.It is sensitive to acidic pH and denatured below pH 4.0. Ammonia methylamine and hydroxylamine (above pH 7.0) cause irreversible conversion to the inactive form.
Datasheet:
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Applications
SDS-PAGE
Application Image
SDS-PAGE
Gene Information
Entrez GeneID:
2
Gene Name:
A2M
Gene Alias:
CPAMD5,DKFZp779B086,FWP007,S863-7
Gene Description:
alpha-2-macroglobulin
Omim ID:
103950, 104300
Gene Ontology:
Hyperlink
Gene Summary:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq
Other Designations:
-
Interactome
Gene Pathway
Complement and coagulation cascades
Related Disease
Alzheimer Disease
Alzheimer disease
Amyloidosis
Arthritis, Rheumatoid
Cardiovascular Diseases
Cognition Disorders
Dementia
Diabetes Complications
Diabetes Mellitus, Type 2
Disease Progression
Diseases in Twins
Edema
Essential Tremor
Essential tremor
Genetic Predisposition to Disease
Hepatitis C, Chronic
Kidney Failure, Chronic
Liver Cirrhosis
Macular Degeneration
... see more
Memory Disorders
Metabolic Syndrome X
Multiple Sclerosis
Myocardial Infarction
Neoplasms
Obesity
Obesity
Osteoporosis
Parkinson Disease
Parkinson disease
... hidden
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