Endo Sis an endoglycosidasewith a uniquely high specificity for removingN-linked glycans from the chitobiose core of theheavy chain of native IgG (1). EndoS is tagged with a chitin binding domain (CBD)for easy removal from a reaction and is suppliedglycerol free for optimal performance in HPLC andMS intensive methods.
Product Source
Endo S is cloned from Streptococcus pyogenes and overexpressed as a fusion to the chitin binding domain in E. coli.
Specificity
Detailed SpecificityX = protein, peptide, Asparagine, or free glycan, as Endo S does not have a strict peptide requirement for activity. Endo S is active on a substrate with or without core α(1-6)fucosylation as well as a with or without a bisecting N-acetylglucosamine. Triantennary and tetrantennary sialyated or asialo glycans are not a substrate for Endo S (1).
This product is related to the following categories:
Endoglycosidases Products,
Proteome Analysis Products
This product can be used in the following applications: