| | CatalogNo.: P-9C1
Description: Neomycinhassuccessfullydeliveredthefollowingphosphoinositidesintocells:PtdIns(4,5)P2,PtdIns(3,4)P2,PtdIns(3,5)P2,PtdIns(3,4,5)P3,andtheirfluorescentanalogs.ThiscarriercanalsobefoundintheseShuttlePIPkits:P-9039,P-9034,P-9045,&P-9035.
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Toprovideourcustomerswithadditionaloptionsindesigningtheirowncell-deliveryapplications,Echelonoffersfluorescentandnon-fluorescentcarriersasstandaloneproductsoutsideourShuttlePIPsTMkits.Customerscanusethemosteffectivecarrierfortheirsystemalongwiththeindividualfluorescentornon-fluorescentphosphoinositidesoftheirchoice.
Providedas2x50nmoles Storage2-8°C,Donotfreezethawmultipletimes.Note:phosphatebuffersarenotrecommendedandmayaltercomplexformationwithphosphoinositides.WedonotrecommendstoringcarriersandPIPstogetherascomplexes.FeaturedinPublications1)Weiner,O.D.,P.O.Neilsen,etal.(2002)."APtdInsP(3)-andRhoGTPase-mediatedpositivefeedbackloopregulatesneutrophilpolarity."NatCellBiol4(7):509-13. 2)Chen,G.,P.Raman,etal.(2004)."ProtectiveEffectofPhosphatidylinositol4,5-BisphosphateagainstCorticalFilamentousActinLossandInsulinResistanceInducedbySustainedExposureof3T3-L1ADIpocytestoInsulin."JBiolChem279(38):39705-39709. 3)Hao,M.andJ.S.Bogan(2009)."Cholesterolregulatesglucose-stimulatedinsulinsecretionthroughphosphatidylinositol4,5-bisphosphate."JBiolChem284(43):29489-98.
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