Echelon/PI(3,4)P2 diC8/1 mg/P-3408

PI(3,4)P2 diC8 (Phosphatidylinositol 3,4-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4)P2.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Product Keywords: Dioctanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 C8, PI(3,4)P2 C8, or PI34P2.

Bulk discounts available, please email echelon@echelon-inc.com for details.

Publication

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1. Elge, S., C. Brearley, et al. (2001). “An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors.” Plant J 26(6): 561-71.2. Tong, Q., N. Gamper, et al. (2004). “Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase.” J Biol Chem 279(21): 22654-63.3. Shen, J., et al. (2009). “Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.” Nat Cell Biol 11(6): 769-776.4. Lopez, S. M., et al. (2013). “Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.” Biochem Biophys Res Commun 440(2): 277-282.5. Choi, S., et al. (2019). “A nuclear phosphoinositide kinase complex regulates p53.” Nature cell biology 21: 462-475.