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Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL
  • Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL

Millipore/MABE16 | Anti-phospho Sir2/SIRT1 (Ser47) Antibody, clone EPR2849Y, rabbit monoclonal/MABE16/100 µL

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货号: MABE16
品牌: Millipore
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    • Description
      CatalogueNumberMABE16
      DescriptionAnti-phosphoSir2/SIRT1(Ser47)Antibody,cloneEPR2849Y,rabbitmonoclonal
      AlternateNames
      • SIR2-likeprotein1
      • sirtuin(silentmatingtypeinformationregulation2homolog)1(S.cerevisiae)
      • sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)1
      BackgroundInformationTheS.cerevisiaesilentinformationregulator2(Sir2)proteinisanNAD+-dependenthistonedeacetylase(HDACs)thatplaysacriticalroleintranscriptionalsilencing,genomestABIlity,andlongevity(1-2).PartoftheSirtuinfamily(Sir2,Sir3,Sir3),yeastSir2isthefoundingmemberofClassIIIHDACs.AhumanhomologueofSir2,SIRT1,regulatestheactivityofthep53tumorsuppressorandinhibitsapoptosis(3-4).
      ProductInformation
      FormatUnpurified
      Control
      • LamBDaphosphatase(LP)-treatedanduntreated293celllysates.
      PresentationRabbitmonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.
      Applications
      ApplicationUseAnti-phosphoSir2/SIRT1(Ser47)Antibody,cloneEPR2849Y(RabbitMonoclonalAntibody)validatedinWB,IHC,ICCtodetectphosphoSir2/SIRT1(Ser47)alsoknownasSIR2-likeprotein1orsirtuin1.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry
      • Immunocytochemistry
      ApplicationNotesImmunohistochemistryAnalysis:A1:250–1:500dilutionfromapreviouslotdetectedSir2/SIRT1inIH.
      ImmunocytochemistryAnalysis:A1:100–1:250dilutionfromapreviouslotdetectedSir2/SIRT1inIC.
      BIOLOGicalInformation
      ImmunogenPhospho-specificpeptidecorrespondingtohumanSir2/SIRT1atSer47.
      EpitopeSer47
      CloneEPR2849Y
      HostRabbit
      SpecificityThisantibodydetectsSir2/SIRT1phosphorylatedonSer47.
      IsotypeIgG
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteProventoreactwithhuman.
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      GeneSymbol
      • sirtuin1
      • SIR2L1
      • hSIR2
      • hSIRT1
      Modifications
      • Phosphorylation
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:NAD-dependentproteindeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsabilitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD+/NADH,whichisessentialinskeletalmusclecelldifferentiation.Deacetylates"Lys-16"ofhistoneH4(invitro).ComponentoftheeNoSC(energy-dependentnucleolarsilencing)complex,acomplexthatmediatessilencingofrDNAinresponsetointracellularenergystatusandactsbyrecruitinghistone-modifyingenzymes.TheeNoSCcomplexisabletosensetheenergystatusofcell:uponglucosestarvation,elevationofNAD+/NADP+ratioactivatesSIRT1,leADIngtohistoneH3deacetylationfollowedbydimethylationofH3at"Lys-9"(H3K9me2)bySUV39H1andtheformationofsilentchromatinintherDNAlocus.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein.
      CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.
      COFACTOR:Binds1zincionpersubunitBysimilarity.
      ENZYMEREGULATION:Inhibitedbynicotinamide.Activatedbyresveratrol(3,5,4"-trihydroxy-trans-stilbene),butein(3,4,2",4"-tetrahydroxychalcone),piceatannol(3,5,3",4"-tetrahydroxy-trans-stilbene),Isoliquiritigenin(4,2",4"-trihydroxychalcone),fisetin(3,7,3",4"-tetrahydroxyflavone)andquercetin(3,5,7,3",4"-pentahydroxyflavone).RPS19BP1/AROSactsasapositiveregulatorofdeacetylationactivity.NegativelyregulatedbyKIAA1967/DBC1.
      SUBUNITSTRUCTURE:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1Bysimilarity.ComponentoftheeNoSCcomplex,composedofSIRT1,SUV39H1andRRP8.InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML.InteractswithRPS19BP1/AROS.InteractswithKIAA1967/DBC1(viaN-terminus).
      SUBCELLULARLOCATION:Nucleus›PMLbody.Note:RecruitedtothenuclearbodiesviaitsinteractionwithPML.
      TISSUESPECIFICITY:Widelyexpressed.
      MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedLifespanasithasbeenobservedinyeast.
      SEQUENCESIMILARITIES:Belongstothesirtuinfamily.
      Contains1deacetylasesirtuin-typedomain.
      SEQUENCECAUTIONS:ThesequenceAAH12499.1differsfromthatshown.Reason:Erroneousinitiation.
      MolecularWeight~110kDaobserved
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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