Mouse monoclonal antibody raised against native Calca.
Immunogen:
Native purified rat Calca.
Host:
Mouse
Reactivity:
Human, Rat
Specificity:
This antibody has been directly tested for reactivity in rat and human. It is expected that This antibody will react with most mammals. specific to Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut.
Form:
Liquid
Purification:
Protein G purification
Isotype:
IgG2a
Recommend Usage:
Immunocytochemistry (1:50-1:100)The optimal working dilution should be determined by the end user.
Storage Buffer:
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 0.1 mg/mL BSA)
Storage Instruction:
Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Datasheet:
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Publication Reference
1.
New therapeutic target in primary headaches - blocking theCGRP receptor.Edvinsson L.Expert Opin Ther Targets. 2003 Jun;7(3):377-83.
2.
Monoclonal antibody to rat alpha-CGRP: production, characterization, and in vivo immunoneutralization activity.Wong HC, Tache Y, Lloyd KC, Yang H, Sternini C, Holzer P, Walsh JH.Hybridoma. 1993 Feb;12(1):93-106.
3.
Calcitonin gene-related peptide is a potent vasodilator.Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I.Nature. 1985 Jan 3-9;313(5997):54-6.
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