Rat monoclonal antibody raised against partial recombinant Abcc5.
Immunogen:
Recombinant protein corresponding to amino acids 1-38 of mouse Abcc5.
Host:
Rat
Reactivity:
Human, Mouse
Specificity:
M5I-10 reacts with an internal epitope of MRP5 (ABCC5), an approximately 160 kD transmembrane protein that is related to the multidrug resistance protein MRP1. The monoclonal antibody also strongly reacts with the human MRP5 protein.
Form:
Liquid
Isotype:
IgG2a
Recommend Usage:
Immunohistochemistry (Frozen sections) (1:20)Immunocytochemistry (1:20-1:50)Wstern Blot (1:20-1:50)The optimal working dilution should be determined by the end user.
Storage Buffer:
In serum-free culture supernatant (0.7% BSA, 0.09% sodium azide)
Storage Instruction:
Store at 4°C.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Publication Reference
1.
Multidrug resistance-associated proteins 3, 4, and 5.Borst P, de Wolf C, van de Wetering K.Borst P, de Wolf C, van de Wetering K.
2.
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH.Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH.
3.
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P.Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P.
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Gene Ontology:
Hyperlink
Other Designations:
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a,ATP-binding cassette, sub-family C (CFTR/MRP), member 5b,ATP-binding cassette, sub-family C, member 5,OTTMUSP00000031743,OTTMUSP00000031744
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