Mouse monoclonal antibody raised against Sialosyl-Tn antigen.
Immunogen:
Ovine submaxillary mucin (OSM).
Host:
Mouse
Reactivity:
Human, Sheep
Specificity:
This antibody stains colon carcinomas and ovarian mucinous carcinomas producing apical cytoplasmic, apical membrane or luminal staining patterns. It is negative with majority of adult tissue sections.
Form:
Liquid
Isotype:
IgG1, kappa
Recommend Usage:
Immunohistochemistry (1:50-1:100)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction:
Store at 4°C.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Publication Reference
1.
Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc.Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD.Cancer Res. 2008 Mar 15;68(6):1636-46.
2.
Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA.Cancer Lett. 2007 May 8;249(2):157-70. Epub 2006 Sep 11.
3.
Monoclonal antibody directed against colon cancer mucin has high specificity for malignancy.Siddiki B, Ho JJ, Huang J, Byrd JC, Lau E, Yuan M, Kim YS.Int J Cancer. 1993 May 28;54(3):467-74.
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