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Millipore/MAB5320 | Anti-Synuclein α Antibody, clone 7B12.2/MAB5320/100 µL
  • Millipore/MAB5320 | Anti-Synuclein α Antibody, clone 7B12.2/MAB5320/100 µL

Millipore/MAB5320 | Anti-Synuclein α Antibody, clone 7B12.2/MAB5320/100 µL

价格: ¥4188.00 市场价: 6980.00
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货号: MAB5320
品牌: Millipore
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    • Description
      CatalogueNumberMAB5320
      Replaces04-1053
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-SynucleinαAntibody,clone7B12.2
      ProductInformation
      FormatCultureSupernatant
      Control
      • Braintissue
      PresentationUnPurifiedtissueculturesupernatantfromaperfusionsystem,filteredthrougha0.2μmicronmembranepriortovialing.Productcontains20%FBSandCiprofloxacinatfinalconcentrationof10μg/mL.
      StorageandShippingInformation
      StorageConditionsMaintainfor1yearat-20°Cfromdateofshipment.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.
      Applications
      ApplicationAnti-SynucleinAntibody,α,clone7B12.2detectslevelofSynuclein&hasbeenpublished&validatedforuseinIH&WB.
      KeyApplications
      • Immunohistochemistry
      • WesternBlotting
      ApplicationNotesWesternblottingonrecombinantalphasynuclein:1:2,000-1:4,000.

      Lane1:Recombinanthumanalphasynuclein

      Lane2:Recombinanthumanbetasynuclein

      Lane3:Recombinanthumangammasynuclein

      Immunohistochemistry(frozensections):1:250-1:500

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenRecombinanthumanalphasynuclein.
      Clone7B12.2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityReactswithalphaSynuclein.ByWesternblottheantibodyshowsnoreactivitywithbetaorgammasynuclein.ThisantibodywasshowntostainLewybodiesinfrozensectionofhumanbrainwithParkinson"sdiseaseandglialinclusionsinfrozensectionofhumanbrainwithMultipleSystemAtrophy.
      IsotypeIgG
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAlpha-synucleinisamemberofthesynucleinfamily,whichalsoincludesbeta-andgamma-synuclein.Synucleinsareabundantlyexpressedinthebrainandalpha-andbeta-synucleininhibitphospholipaseD2selectively.SNCAmayservetointegratepresynapticsignalingandmembranetrafficking.DefectsinSNCAhavebeenimplicatedinthepathogenesisofParkinsondisease.SNCApeptidesareamajorcomponentofamyloidplaquesinthebrainsofpatientswithAlzheimer"sdisease.TwoalternativelysplicedtranscriptsofSNCAhavebeenidentified.Additionalsplicingmaybepresentbutthefull-lengthnatureofthesevariantshasnotbeendetermined.
      GeneSymbol
      • SNCA
      • PD1
      • alpha-synuclein
      • NACP
      • PARK4
      • MGC110988
      • PARK1
      • Alpha-synuclein
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P37840#Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase3activation.
      SIZE:140aminoacids;14460Da
      SUBUNIT:Solublemonomerwhichcanformfilamentousaggregates.InteractswithUCHL1(Bysimilarity).InteractswithphospholipaseDandhistones.
      SUBCELLULARLOCATION:Cytoplasm.Membrane.Nucleus.Note=Membrane-boundindopaminergicneurons.Alsofoundinthenucleus.
      TISSUESPECIFICITY:Expressedprincipallyinbrainbutisalsoexpressedinlowconcentrationsinalltissuesexaminedexceptinliver.Concentratedinpresynapticnerveterminals.
      DOMAIN:SwissProt:P37840TheNACdomainisinvolvedinthefibrilformation.Themiddleregionformsthecoreofthefilaments.TheC-terminusmayregulateaggregationanddeterminethediameterofthefilaments.
      PTM:Phosphorylated,predominantlyonserineresidues.PhosphorylationbyCK1appearstooccuronresiduesdistinctfromtheresiduephosphorylatedbyotherkinases.PhosphorylationofSer-129isselectiveandextensiveinsynucleinopathylesions.Invitro,phosphorylationatSer-129promotedinsolublefibrilformation.PhosphorylatedonTyr-125byaPTK2B-dependentpathwayuponosmoticstress.&Hallmarklesionsofneurodegenerativesynucleinopathiescontainalpha-synucleinthatismodifiedbynitrationoftyrosineresiduesandpossIBLybydityrosinecross-linkingtogeneratedstableoligomers.&Ubiquitinated.Thepredominantconjugateisthediubiquitinatedform(Bysimilarity).
      DISEASE:SwissProt:P37840#DefectsinSNCAareacauseofautosomaldominantParkinsondisease1(PARK1)[MIM:168601,168600].Parkinsondisease(PD)isacomplex,multifactorialdisorderthattypicallymanifestsaftertheageof50years,althoughearly-onsetcases(before50years)areknown.PDgenerallyarisesasasporadicconditionbutisoccasionallyinheritedasasimplemendeliantrait.AlthoughsporadicandfamilialPDareverysimilar,inheritedformsofthediseaseusuallybeginatearlieragesandareassociatedwithatypicalclinicalfeatures.PDischaracterizedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain.&DefectsinSNCAarethecauseofParkinsondisease4(PARK4)[MIM:605543,168600].&DefectsinSNCAarethecauseofLewybodydementia(DLB)[MIM:127750].DLBisaneurodegenerativedisorderclinicallycharacterizedbydementiaandparkinsonism,oftenwithfluctuatingcognitivefunction,visualhallucinations,falls,syncopalepisodes,andsensitivitytoneurolepticmedication.PresenceofLewybodiesaretheonlyessentialpathologicfeatures.&DepositionoffibrillaramyloidproteinsintraneuronallyasneurofibrillarytanglesischaracteristicofAlzheimerdisease(AD).SNCAisaminorproteinfoundwithinthesedeposits,butamajornonamyloidcomponent.&Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCAisfoundinLB-likeinclusions,glialinclusionsandspheroids.
      SIMILARITY:Belongstothesynucleinfamily.
      MolecularWeight15-18kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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