BackgroundInformation | Synaptophysinisa38kDaglycoproteinpresentinthemembraneofneuronalpresynapticvesiclesinbrain,spinalcord,retina,vesiclesofadrenalmedulla,neuromuscularjunctions,andendocrinecells.Itisalsoexpressedbyneuroendocrinecellsthroughoutthebody,bothnormalandneoplastic.SynaptophysinisausefulMarkerfortheidentificationofnormalneuroendocrinecellsandneuroendocrineneoplasms.Thisantibodyreactswithneuroendocrinecellsofhumanadrenalmedulla,carotidbody,skin,pituitarygland,thyroid,lung,pancreas,andgastointestinalmucosa.Italsoreactswithawidespectrumofneuroendocrineneoplasmsofneuraltypeincludingneuroblastomas,ganglioneuroblastomas,ganglioneuromas,pheochromocytomas,chromaffin,andnonchromaffinparagangliomas. |