Flow Cytometry (20 uL/106 cells)The optimal working dilution should be determined by the end user.
Storage Buffer:
In buffer containing 1% BSA, pH 7.2 (0.09% sodium azide).
Storage Instruction:
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Publication Reference
1.
The "ex vivo" patterns of CD2/CD7, CD57/CD11c, CD38/CD11b, CD45RA/CD45RO, and CD11a/HLA-DR expression identify acute/early and chronic/late NK-cell activation states.Lima M, Almeida J, dos Anjos Teixeira M, Queiros ML, Justica B, Orfao A.Blood Cells Mol Dis. 2002 Mar-Apr;28(2):181-90.
2.
Immunophenotyping of non-Hodgkin"s lymphomas using a panel of antibodies on paraffin-embedded tissues.Davey FR, Gatter KC, Ralfkiaer E, Pulford KA, Krissansen GW, Mason DY.Am J Pathol. 1987 Oct;129(1):54-63.
Applications
Immunofluorescence
Flow Cytometry
Flow Cytometry using human peripheral blood cells (1 ug/106 cells).FACSCalibur (Becton Dickinson, San Jose, CA) flow cytometer, using Cell Quest acquisition software and PAINT-A-GATE. PRO, analysis software.
Application Image
Immunofluorescence
Flow Cytometry
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Gene Information
Entrez GeneID:
5788
Gene Name:
PTPRC
Gene Alias:
B220,CD45,CD45R,GP180,LCA,LY5,T200
Gene Description:
protein tyrosine phosphatase, receptor type, C
Omim ID:
126200, 151460, 609532
Gene Ontology:
Hyperlink
Gene Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations:
CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
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