Immunogen | Bovinebrainmicrotubuleprotein. |
Clone | AP20 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | MAB3418bindsspecificallytoMAP-2. |
Isotype | IgG |
SpeciesReactivity | - Bovine
- Chicken
- Human
- Mouse
- Rat
- Xenopus
- Quail
|
SpeciesReactivityNote | Ratandmouse.Expectedtocross-reactwithhuman,cow,chicken,quail,andXenopus. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesaproteinthatbelongstothemicrotubule-associatedproteinfamily.Theproteinsofthisfamilyarethoughttobeinvolvedinmicrotubuleassembly,whichisanessentialstepinneurogenesis.Theproductsofsimilargenesinratandmouseareneuron-specificcytoskeletalproteinsthatareenrichedindentrites,implicatingaroleindeterminingandstABIlizingdentriticshapeduringneurondevelopment.Anumberofalternativelysplicedvariantsencodingdistinctisformshavebeendescribed. |
GeneSymbol | - MAP2
- MAP2B
- MAP-2
- MAP2C
- DKFZp686I2148
- MAP2A
|
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P11137#TheexactfunctionofMAP2isunknownbutMAPsmaystabilizethemicrotubulesagainstdepolymerization.Theyalsoseemtohaveastiffeningeffectonmicrotubules. SIZE:1827aminoacids;199539Da PTM:MAP2A/cisphosphorylated.PhosphorylateduponDNAdamage,probablybyATMorATR. SIMILARITY:SwissProt:P11137##Contains3Tau/MAPrepeats. |
MolecularWeight | 230kDa |