Immunogen | Humanpheochromocytoma |
Clone | PHE5 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | ChromograninA.Theantibodyhasbeenextensivelydocumentedonimmunohistochemicalstudiesindeparaffinizedmethacarnfixedtissue,whereitisasensitiveMarkerofneuroendocrinecellsandtumors.Notrecommendedforformalinfixedtissues,seeMAB5268orCBL219.Onwesternblots,itidentifiestheidenticalbandsrecognizedbyantibodyLK2H10(WilsonandLloyd). |
Isotype | IgG1 |
SpeciesReactivity | |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Theproteinencodedbythisgeneisamemberofthechromogranin/secretograninfamilyofneuroendocrinesecretoryproteins.Itisfoundinsecretoryvesiclesofneuronsandendocrinecells.Thisgeneproductisaprecursortothreebiologicallyactivepeptides;vasostatin,pancreastatin,andparastatin.Thesepeptidesactasautocrineorparacrinenegativemodulatorsoftheneuroendocrinesystem.Otherpeptides,includingchromostatin,beta-granin,WE-14andGE-25,arealsoderivedfromthefull-lengthprotein.However,biologicalactivitiesforthesemoleculeshavenotbeenshown. |
GeneSymbol | |
Non-ReactiveSpecies | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P10645#Pancreastatinstronglyinhibitsglucoseinducedinsulinreleasefromthepancreas. SIZE:457aminoacids;50730Da SUBCELLULARLOCATION:Secreted.Note=Neuroendocrineandendocrinesecretorygranules. PTM:Sulfatedontyrosineresiduesand/orcontainssulfatedglycans. SIMILARITY:SwissProt:P10645##Belongstothechromogranin/secretograninproteinfamily. MISCELLANEOUS:Bindscalciumwithalow-affinity. |