Mouse monoclonal antibody raised against human ANPEP.
Immunogen:
Human AML cells.
Host:
Mouse
Theoretical MW (kDa):
150
Reactivity:
Human
Form:
Liquid
Purification:
Protein A/G purification
Isotype:
IgG1, kappa
Recommend Usage:
Flow Cytometry (0.5-1 ug/106 cells)Immunofluorescence (1-2 ug/mL)Immunohistochemistry (Frozen sections) (0.5-1 ug/mL)The optimal working dilution should be determined by the end user.
Storage Buffer:
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction:
Store at 4°C.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Applications
Immunohistochemistry (Frozen sections)
Immunofluorescence
Flow Cytometry
Application Image
Immunohistochemistry (Frozen sections)
Immunofluorescence
Flow Cytometry
Gene Information
Entrez GeneID:
290
Protein Accession#:
P15144
Gene Name:
ANPEP
Gene Alias:
APN,CD13,LAP1,PEPN,gp150,p150
Gene Description:
alanyl (membrane) aminopeptidase
Omim ID:
151530
Gene Ontology:
Hyperlink
Gene Summary:
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
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