Rabbit monoclonal antibody raised against synthetic peptide of human CASP3 p12.
Immunogen:
A synthetic peptide corresponding to human CASP3 p12.
Host:
Rabbit
Theoretical MW (kDa):
31.608
Reactivity:
Human
Form:
Liquid
Purification:
Affinity purification
Isotype:
IgG
Recommend Usage:
Immunocytochemistry (1:50-1:200)Immunofluorescence (1:50-1:200)Immunohistochemistry (1:100-1:500)ImmunoprecipitationWestern Blot (1:500-1:1000)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction:
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HeLa cell lysate with CASP3 p12 monoclonal antibody, clone GEA-3 (Cat # MAB19700).
Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Application Image
Western Blot (Cell lysate)
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Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Gene Information
Entrez GeneID:
836
Protein Accession#:
P42574
Gene Name:
CASP3
Gene Alias:
CPP32,CPP32B,SCA-1
Gene Description:
caspase 3, apoptosis-related cysteine peptidase
Omim ID:
600636
Gene Ontology:
Hyperlink
Gene Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer"s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
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