UniProtSummary | FUNCTION:SwissProt:P78352#InteractswiththecytoplasmictailofNMDAreceptorsubunitsandshaker-typepotassiumchannels.RequiredforsynapticplasticityassociatedwithNMDAreceptorsignaling.OverexpressionordepletionofDLG4changestheratioofexcitatorytoinhibitorysynapsesinhippocampalneurons.MayreducetheamplitudeofACCN3acid-evokedcurrentsbyretainingthechannelintracellularly.MayregulatetheintracellulartraffickingofADR1B(Bysimilarity). SIZE:724aminoacids;80495Da SUBUNIT:InteractsthroughitsfirsttwoPDZdomainswithGRIN2A,GRIN2B,GRIN2C,GRIN2D,ACCN3,certainspliceformsofGRIN1,KCND2,CXADRandSYNGAP1.InteractsthroughitssecondPDZdomainwiththePDZdomainofNOS1ortheC-terminusofCAPON.MayinteractwithHTR2A.Interactsthroughitsguanylatekinase-likedomainwithDLGAP1/GKAP,DLGAP2,DLGAP3,DLGAP4,MAP1A,andBEGAIN(Bysimilarity).InteractsthroughitsfirsttwoPDZdomainswithKCNA1,KCNA2,KCNA3,KCNA4andERBB4.InteractsthroughitsfirstPDZdomainwithGRIK2,KCNA4andCRIPT.InteractsthroughitsthirdPDZdomainwithNLGN1,andprobablywithNLGN2andNLGN3.Interactsthroughitsguanylatekinase-likedomainwithKIF13B.Isoform2interactsthroughanL27domainwithHGS/HRSandthefirstL27domainofCASK. SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein.Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity.Celljunction,synapse.Note=Highlevelsinpostsynapticdensityofneuronsintheforebrain.AlsoinpresynapticregionofinhibitorysynapsesformedbycerebellarbasketcellsonaxonhillocksofPurkinjecells. TISSUESPECIFICITY:Brain. DOMAIN:SwissProt:P78352ThePDZdomain3mediatesinteractionwithADR1B.&TheL27domainneartheN-terminusofisoform2isrequiredforHGS/HRS-dependenttargetingtopost-synapticdensity. PTM:Palmitoylationofisoform1isrequiredfortargetingtopostsynapticdensity(Bysimilarity). SIMILARITY:BelongstotheMAGUKfamily.&Contains1guanylatekinase-likedomain.&Contains3PDZ(DHR)domains.&Contains1SH3domain. |