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Millipore/MAB1548 | Anti-Myosin Antibody, heavy chain β/MAB1548/1 mL
  • Millipore/MAB1548 | Anti-Myosin Antibody, heavy chain β/MAB1548/1 mL

Millipore/MAB1548 | Anti-Myosin Antibody, heavy chain β/MAB1548/1 mL

价格: ¥3948.00 市场价: 6580.00

货号: MAB1548
品牌: Millipore
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    • Description
      CatalogueNumberMAB1548
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-MyosinAntibody,heavychainβ
      ProductInformation
      FormatCultureSupernatant
      PresentationSupernatantinRPMI1640,10%FCS,0.01%sodiumazide.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12months.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationDetectMyosinusingthisAnti-MyosinAntibody,heavychainβvalidatedforuseinWB,IH.
      KeyApplications
      • WesternBlotting
      • Immunohistochemistry
      ApplicationNotesImmunohistochemistry:Neat(undiluted)
      Westernblot:1:10

      Optimaldilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenHumanventricularmyosin
      Epitopeheavychainbeta
      Clone5B9(aka2C8)
      HostMouse
      SpecificityRecognizestheS1/S2junctionofhumanventricularmyosinheavychainbeta
      IsotypeIgG2a
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryMYH7encodesthecardiacmusclebeta(orslow)isoformofmyosin.ChangesintherelativeabundanceofMYH7andMYH6(thealpha,orfast,isoformofcardiacmyosinheavychain)correlatewiththecontractilevelocityofcardiacmuscle.MutationsinMYH7areassociatedwithfamilialhypertrophiccardiomyopathy.
      GeneSymbol
      • MYH7
      • Myosin-7
      • MYHCB
      • MyHC-beta
      • DKFZp451F047
      • CMH1
      • CMD1S
      • MGC138378
      • MPD1
      • MGC138376
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P12883#Musclecontraction.
      SIZE:1935aminoacids;223097Da
      SUBUNIT:Musclemyosinisahexamericproteinthatconsistsof2heavychainsubunits(MHC),2alkalilightchainsubunits(MLC)and2regulatorylightchainsubunits(MLC-2).
      SUBCELLULARLOCATION:Cytoplasm,myofibril.Note=Thickfilamentsofthemyofibrils.
      DOMAIN:SwissProt:P12883Therodliketailsequenceishighlyrepetitive,showingcyclesofa28-residuerepeatpatterncomposedof4heptapeptides,characteristicforalpha-helicalcoiledcoils.
      DISEASE:SwissProt:P12883#DefectsinMYH7arethecauseoffamilialhypertrophiccardiomyopathytype1(CMH1)[MIM:192600];alsodesignatedFHCorHCM.Hypertrophiccardiomyopathyisaheartdisordercharacterizedbyventricularhypertrophy,whichisusuallyasymmetricandofteninvolvestheinterventricularseptum.Theprevalenceofthediseaseinthegeneralpopulationis0.2%.FHCisclinicallyheterogeneous,withinter-andintrafamilialvariationsrangingfrombenigntomalignantformswithhighriskofcardiacfailureandsuddencardiacdeath.&DefectsinMYH7arethecauseofmyosinstoragemyopathy[MIM:608358].Inthisdisorder,musclebiopsyshowstype1fiberpredominanceandincreasedinterstitialfatandconnectivetissue.Inclusionbodiesconsistingofthebetacardiacmyosinheavychainarepresentinthemajorityoftype1fibers,butnotintype2fibers.&DefectsinMYH7areacauseofdilatedcardiomyopathy(CMD)[MIM:115200].CMDisadisordercharacterizedbycardiacdilationandreducedsystolicfunction.&DefectsinMYH7arethecauseofLaingearly-onsetdistalmyopathy(MPD1)[MIM:160500].MPD1isanautosomaldominantdisorderwhichdiffersfromotherdistalmyopathiesinthatonsetisasearlyas4yearsofage.SelectiveweaknessoftheanteriortibialmusclesisfollowedbyweaknessofthefingerextensorsandselectedproximalmusclegroupssuchasthehipaBDuctorsandrotators,theshoulderabductorsandthesternocleidomastoids.
      SIMILARITY:Contains1IQdomain.&Contains1myosinhead-likedomain.
      MISCELLANEOUS:Eachmyosinheavychaincanbesplitinto1lightmeromyosin(LMM)and1heavymeromyosin(HMM).Itcanlaterbesplitfurtherinto2globularsubfragments(S1)and1rod-shapedsubfragment(S2).&Thecardiacalphaisoformisa"fast"ATPasemyosin,whilethebetaisoformisa"slow"ATPase.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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