Rabbit monoclonal antibody raised against synthetic phosphopeptide of human ACACA/ACACB.
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding S79 of human ACACA/ACACB.
Host:
Rabbit
Reactivity:
Human
Form:
Liquid
Purification:
Protein A purification
Isotype:
IgG
Recommend Usage:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2000)Western Blotting (1:1000-1:5000)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction:
Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Datasheet:
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Applications
Western Blot (Cell lysate)
Western Blot analysis of A431 cell lysate Lane 1: nontreated and Lane 2: treated with Lambda Protein Phosphatase with ACACA/ACACB (phospho S79) monoclonal antibody, clone RM270 (Cat # MAB14918).
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with ACACA/ACACB (phospho S79) monoclonal antibody, clone RM270 (Cat # MAB14918).
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5" sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria.ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis.There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq
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