Mouse monoclonal antibody raised against human CD45RA.
Immunogen:
Fresh human lymph node lymphocytes depleted of surface immunoglobulin positive cells.
Host:
Mouse
Theoretical MW (kDa):
220
Reactivity:
Human
Form:
Liquid
Conjugation:
Biotin
Purification:
Protein A/G purification
Purity:
>90%
Isotype:
IgG2b, kappa
Recommend Usage:
Flow Cytometry (1 ug/106 cells)ImmunofluorescenceImmunohistochemistry (Frozen sections)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
Storage Instruction:
Store in the dark at 4°C.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations:
CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
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