T4 PDG (pyrimidine dimer glycosylase) has both DNA glycosylase and APlyase activity. The 16 kd protein recognizes cis-syn-cyclobutane pyrimidine dimers caused by UV irradiation. The enzyme cleaves the glycosyl bond of the 5´ end of the pyrimidine dimer and the endonucleolytic activity cleaves the phosphodiester bond at the AP site.
Product Source
Purified from an E. coli strain carrying a plasmid encoding T4 denV gene.
This product is related to the following categories:
DNA Repair Enzymes and Structure-specific Endonucleases Products