Alkyl-OMPT (D-sn-1-O-oleyl-2-O-methyl-glyceryl-3-phosphothionate) is a potent agonist for the G-protein-coupled LPA 3 receptor. Alkyl OMPT induces cell migration in cancer cells mediated by activation of LPA1. Alkyl OMPT also activated Ca2+ release via LPA2 activation but with reduced potency relative to sn-1-oleoyl LPA.