This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq
Other Designations:
AH-receptor,aromatic hydrocarbon receptor
Gene Information
Entrez GeneID:
57491
Protein Accession#:
P35869 (Gene ID : 196);A9YTQ3 (Gene ID : 57491)
Gene Name:
AHRR
Gene Alias:
AHH,AHHR,KIAA1234,MGC167813,MGC176630,bHLHe77
Gene Description:
aryl-hydrocarbon receptor repressor
Omim ID:
606517
Gene Ontology:
Hyperlink
Gene Summary:
Dioxin is a teratogen that exerts its effects through the arylhydrocarbon receptor in conjunction with the receptor"s binding partner, arylhydrocarbon receptor nuclear translocator. The protein encoded by this gene represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B. [provided by RefSeq
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4000-520-616
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