Phosphorylated NEFH (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of phosphorylated NEFH.
Limit of Detection:
24 pg/mL
Quality Control Testing:
Standard CurveThe standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction:
Store at 4°C on dry atmosphere away from light.
Protocol:
Protocol Download
MSDS:
Download
Suitable Sample:
Cerebrospinal Fluid, Plasma, Serum
Sample Volume:
100 uL (diluted)
Label:
HRP-conjugate
Detection Method:
Colorimetric
Regulation Status:
For research use only (RUO)
Datasheet:
Download
Publication Reference
1.
Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis.Håkansson I, Tisell A, Cassel P, Blennow K, Zetterberg H, Lundberg P, Dahle C, Vrethem M, Ernerudh J.J Neuroinflammation. 2018 Jul 18;15(1):209.
2.
Neurofilament light chain in cerebrospinal fluid and prediction of disease activity in clinically isolated syndrome and relapsing-remitting multiple sclerosis.Håkansson I, Tisell A, Cassel P, Blennow K, Zetterberg H, Lundberg P, Dahle C, Vrethem M, Ernerudh J.Eur J Neurol. 2017 May;24(5):703-712. doi: 10.1111/ene.13274. Epub 2017 Mar 6.
Applications
Quantification
Application Image
Quantification
Gene Information
Entrez GeneID:
4744
Gene Name:
NEFH
Gene Alias:
NFH
Gene Description:
neurofilament, heavy polypeptide
Omim ID:
105400, 162230
Gene Ontology:
Hyperlink
Gene Summary:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
Other Designations:
neurofilament triplet H protein,neurofilament, heavy polypeptide 200kDa