ProductBackground:CarboxymethylLysine(CML)isanadvancedglycationendproduct(AGE)formedbyoxidativestressandglycosylation.AGE's,includingCML,canaccumulateintissuescausinginflammation.ExcessiveAGE'salsoreduceantioxidantdefense,weakenimmunesystems,impairDNArepairmechanisms,andpromotetheaccumulationoftoxinsandinfectionsintissues.CMLadductshavebeenfoundtoaccumulateinmanydiseasesincludingAlzheimersdisease,diabetes,chronicobstructivepulmonarydisease(COPD),acceleratedperiodontaldisease,renaldisease,andatherosclerosis. CMLinthesamplecompeteswithplate-boundCMLforantibodybinding;adecreasingsignalintheplateindicatesanincreasingCMLconcentrationinthesample.
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