Productbackground:CollagenIVisamajorcomponentoftheextracellularmatrixandprovidesthemainstructuralsupportforthebasementmembrane.IthasbeendemonstratedthatavarietyofdiseasescausealterationsinCollagenIVsynthesis,degradationandreleaseatthetissuelevel.TheserumlevelofCollagenIVisalteredinseveraltypesofdiseases,includingliverfibrosis(agoodindexwithhyaluronicacid)andcirhosis.ResearchhasshownthatthelossofCollagenIVinthebasementmembrane(withaconcurrentincreaseinCollagenaseactivity)positivelycorrelateswiththeprogressionofcancer.CollagenIVintheseramaybeindicativeoftissueCollagenIVdegradationandmaycorrelatewithcancerprogression.
Echelon'sCollagenIVELISAKitIIisaquantitativesandwichimmunoassydesignedforinvitromeasurementofcollagenIVlevelsinBIOLOGicalsamples.TheconcentrationofcollagenIVwiththesampleisdeterminedusingastandardcurveofknownamountsofcollagenIV.
RelatedProducts: HyaluronanEnzyme-LinkedImmunosorbentAssay(K-1200) HyaluronicAcidSandwichELISA(K-4800) CollagenIVAssayService(T-1700)
Keywords:Hyaluronan,Liverfibrosis,COL4A1,COL4A2,COL4A3,COL4A4,COL4A5,COL4A6
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