This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACVR1B.
Reactivity:
Human
Quality Control Testing:
Standard curve using recombinant protein ( H00000091-Q01 ) as an analyte.Sandwich ELISA detection sensitivity ranging from 10 ng/ml to 100 ng/ml.
Supplied Product:
Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-ACVR1B, IgG1 Kappa (100 ug) 2. Detection antibody: biotinylated mouse monoclonal anti-ACVR1B, IgG1 Kappa (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
Storage Instruction:
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
Datasheet:
Download
Applications
ELISA Pair (Recombinant protein)
Protocol Download
Application Image
ELISA Pair (Recombinant protein)
Gene Information
Entrez GeneID:
91
Gene Name:
ACVR1B
Gene Alias:
ACTRIB,ACVRLK4,ALK4,SKR2
Gene Description:
activin A receptor, type IB
Omim ID:
601300
Gene Ontology:
Hyperlink
Gene Summary:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
Other Designations:
activin A receptor, type II-like kinase 4,activin A type IB receptor,activin receptor-like kinase 4,serine(threonine) protein kinase receptor R2
Gene Pathway
Adherens junction
Chronic myeloid leukemia
Colorectal cancer
Cytokine-cytokine receptor interaction
Endocytosis
MAPK signaling pathway
Pancreatic cancer
Pathways in cancer
TGF-beta signaling pathway
Related Disease
Genetic Predisposition to Disease
Head and Neck Neoplasms
Neoplasm Recurrence, Local
Neoplasms, Second Primary
Obesity
Ovarian Failure, Premature
Polycystic Ovary Syndrome
Puberty, Delayed
Puberty, Precocious
Schizophrenia
Thrombophilia
Tobacco Use Disorder
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XIAP & ACVR1B Protein Protein Interaction Antibody Pair