Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer:
In 1x PBS, pH 7.4
Storage Instruction:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
MSDS:
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Interspecies Antigen Sequence:
Mouse (73); Rat (69)
Datasheet:
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Publication Reference
1.
N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.Muta K, Fukami T, Nakajima M, Yokoi TBiochem Pharmacol. 2013 Oct 11. pii: S0006-2952(13)00651-5. doi: 10.1016/j.bcp.2013.10.001.
2.
Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.Kobayashi Y, Fukami T, Higuchi R, Nakajima M, Yokoi T.Biochem Pharmacol. 2012 Aug 23.
3.
A Novel Polymorphic Allele of Human Arylacetamide Deacetylase Leads to Diminished Enzyme Activity.Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, Yokoi T.Drug Metab Dispos. 2012 Mar 13. [Epub ahead of print]
4.
Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.Kobayashi Y, Fukami T, Nakajima A, Watanabe A, Nakajima M, Yokoi T.Drug Metab Dispos. 2012 Apr;40(4):671-9. Epub 2011 Dec 29.
5.
Human Arylacetamide Deacetylase Is A Principal Enzyme in Flutamide Hydrolysis.Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T.Drug Metab Dispos. 2009 Jul;37(7):1513-20. Epub 2009 Apr 1.
Applications
Western Blot (Recombinant protein)
Protocol Download
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged AADAC is approximately 3ng/ml as a capture antibody.
Protocol Download
ELISA
Application Image
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
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ELISA
Gene Information
Entrez GeneID:
13
GeneBank Accession#:
NM_001086
Protein Accession#:
NP_001077
Gene Name:
AADAC
Gene Alias:
CES5A1,DAC
Gene Description:
arylacetamide deacetylase (esterase)
Omim ID:
600338
Gene Ontology:
Hyperlink
Gene Summary:
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq
Other Designations:
arylacetamide deacetylase
Gene Pathway
Tropane, piperidine and pyridine alkaloid biosynthesis