Rabbit monoclonal antibody raised against a human A2M peptide using ARM Technology.
Immunogen:
A synthetic peptide of human A2M is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence.
Host:
Rabbit
Reactivity:
Human
Purification:
Protein A
Isotype:
IgG
Quality Control Testing:
Antibody reactive against human A2M peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer:
In 1x PBS, pH 7.4
Storage Instruction:
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note:
1. Customer may provide cell or tissue lysate for antibody screening.2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
Library Construction:
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression:
Overexpression vector and transfection into 293H cell line.
Deliverable:
Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
Datasheet:
Download
Applications
Western Blot (Transfected lysate)
Protocol Download
ELISA
Application Image
Western Blot (Transfected lysate)
ELISA
Gene Information
Entrez GeneID:
2
GeneBank Accession#:
A2M
Gene Name:
A2M
Gene Alias:
CPAMD5,DKFZp779B086,FWP007,S863-7
Gene Description:
alpha-2-macroglobulin
Omim ID:
103950, 104300
Gene Ontology:
Hyperlink
Gene Summary:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq
Other Designations:
-
Interactome
Gene Pathway
Complement and coagulation cascades
Related Disease
Alzheimer Disease
Alzheimer disease
Amyloidosis
Arthritis, Rheumatoid
Cardiovascular Diseases
Cognition Disorders
Dementia
Diabetes Complications
Diabetes Mellitus, Type 2
Disease Progression
Diseases in Twins
Edema
Essential Tremor
Essential tremor
Genetic Predisposition to Disease
Hepatitis C, Chronic
Kidney Failure, Chronic
Liver Cirrhosis
Macular Degeneration
... see more
Memory Disorders
Metabolic Syndrome X
Multiple Sclerosis
Myocardial Infarction
Neoplasms
Obesity
Obesity
Osteoporosis
Parkinson Disease
Parkinson disease
... hidden
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