Labeled FISH probes for identification of gene transloaction using Fluoresecent In Situ Hybridization Technique. (Technology)
Form:
Liquid
Quality Control Testing:
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product:
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction:
Store at 4°C in the dark.
Note:
Hybridization position of the probes on the chromosome:
Probe 1:Size:Fluorophore:Location:
DDIT3Approximately 280kbTexas Red12q13.3
Probe 2:Size:Fluorophore:Location:
FUSApproximately 550kbFITC16p11.2
Origin:
Human
Source:
Genomic DNA
Notice:
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status:
For research use only (RUO)
Datasheet:
Download
Applications
Fluorescent In Situ Hybridization (Cell)
Protocol Download
Application Image
Fluorescent In Situ Hybridization (Cell)
DDIT3
FUS
Gene Information
Entrez GeneID:
1649
Gene Name:
DDIT3
Gene Alias:
CEBPZ,CHOP,CHOP10,GADD153,MGC4154
Gene Description:
DNA-damage-inducible transcript 3
Omim ID:
126337
Gene Ontology:
Hyperlink
Other Designations:
C/EBP homologous protein,C/EBP zeta,CCAAT/enhancer-binding protein homologous protein,growth arrest- and DNA damage-inducible
Gene Information
Entrez GeneID:
2521
Gene Name:
FUS
Gene Alias:
CHOP,FUS-CHOP,FUS1,TLS,TLS/CHOP,hnRNP-P2
Gene Description:
fusion (involved in t(12;16) in malignant liposarcoma)
Omim ID:
137070
Gene Ontology:
Hyperlink
Gene Summary:
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq
Other Designations:
FUS-CHOP fusion protein,FUS-CHOP protein fusion,Fusion gene in myxoid liposarcoma,fus-like protein,fus/tls-chop oncogene,heterogeneous nuclear ribonucleoprotein P2,translocated in liposarcoma
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