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Abnova/EML4/ALK DY Translocation FISH Probe/1kit/FT0001
  • Abnova/EML4/ALK DY Translocation FISH Probe/1kit/FT0001

Abnova/EML4/ALK DY Translocation FISH Probe/1kit/FT0001

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货号: FT0001
品牌: Abnova
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      • Specification
      • Gene Info
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology)
      • Form:
      • Liquid
      • Quality Control Testing:
      • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.QC Testing of FT0001
      • Supplied Product:
      • DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Note:
      • Hybridization position of the probes on the chromosome.
      • Probe 1:Size:Fluorophore:Location:
      • EML4Approximately 1130kbFITC2p22-p21
      • Probe 2:Size:Fluorophore:Location:
      • ALKApproximately 700kbTexas Red2p23
      • Probe Gap:
      • The gap between two probes is approximately 13,900 kb.
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulation Status:
      • For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)enlargeenlarge this image
      • Human lung, adenosquamous cell carcinoma (FFPE) stained with EML4/ALK DY Translocation FISH Probe. Human lung, adenosquamous cell carcinoma showed no EML4/ALK DY Translocation.
      • PDF DownloadProtocol Download
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)enlargeenlarge this image
      • Human stomach carcinoma (FFPE) stained with EML4/ALK DY Translocation FISH Probe. Human stomach carcinoma showed no EML4/ALK DY Translocation.
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • ALK
      • EML4
      • Gene Information
      • Entrez GeneID:
      • 27436
      • Gene Name:
      • EML4
      • Gene Alias:
      • C2orf2,DKFZp686P18118,ELP120,FLJ10942,FLJ32318,ROPP120
      • Gene Description:
      • echinoderm microtubule associated protein like 4
      • Omim ID:
      • 607442
      • Gene Ontology:
      • Hyperlink
      • Other Designations:
      • -
      • Gene Information
      • Entrez GeneID:
      • 238
      • Gene Name:
      • ALK
      • Gene Alias:
      • CD246,Ki-1,TFG/ALK
      • Gene Description:
      • anaplastic lymphoma receptor tyrosine kinase
      • Omim ID:
      • 105590
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3" half of ALK, derived from chromosome 2, is fused to the 5" portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
      • Other Designations:
      • ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
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