Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
Form:
Liquid
Quality Control Testing:
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product:
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction:
Store at 4°C in the dark.
Note:
Hybridization position of the probes on the chromosome.
Probe 1:Size:Fluorophore:Location:
BCORApproximately 350kb TexRedXp11.4
Probe 2:Size:Fluorophore:Location:
BCORApproximately 430kb FITCXp11.4
Origin:
Human
Source:
Genomic DNA
Notice:
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status:
For research use only (RUO)
Datasheet:
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Publication Reference
1.
A Case Series of BCOR Sarcomas With a New Splice Variant of BCOR/CCNB3 Fusion Gene.Anastasios Kyriazoglou, Natalia Tourkantoni, Michalis Liontos, Flora Zagouri, Louisa Mahaira, Alexandra Papakosta, Dimitra Michali, Amalia Patereli, Kalliopi Stefanaki, Vasiliki Tzotzola, Evangelia Skoura, Margarita Baka, Sofia Polychronopoulou, Antonis Kattamis, Efthymios Dimitriadis.In Vivo. Sep-Oct 2020;34(5):2947-2954. doi: 10.21873/invivo.12125.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
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