Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
Form:
Liquid
Quality Control Testing:
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product:
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction:
Store at 4°C in the dark.
Note:
Hybridization position of the probes on the chromosome.
Probe 1:Size:Fluorophore:Location:
BRAFApproximately 460kb TexRed7q34
Probe 2:Size:Fluorophore:Location:
BRAFApproximately 810kb FITC7q34
Origin:
Human
Source:
Genomic DNA
Notice:
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status:
For research use only (RUO)
Datasheet:
Download
Applications
Fluorescent In Situ Hybridization (Cell)
Protocol Download
Application Image
Fluorescent In Situ Hybridization (Cell)
Gene Information
Entrez GeneID:
673
Gene Name:
BRAF
Gene Alias:
B-RAF1,BRAF1,FLJ95109,MGC126806,MGC138284,RAFB1
Gene Description:
v-raf murine sarcoma viral oncogene homolog B1
Omim ID:
115150, 164757, 211980
Gene Ontology:
Hyperlink
Gene Summary:
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq
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