Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique.
Storage Instruction:
Store at 4°C in the dark.
Note:
Hybridization position of the probes on the chromosome.
Probe 1:Size:Fluorophore:Location:
ALKApproximately 335 kbTexas Red2p23.3
Probe 2:Size:Fluorophore:Location:
ALKApproximately 370 kbFITC2p23.3
Probe Gap:
The gap between two probes is approximately 174 kb
Origin:
Human
Source:
Genomic DNA
Regulation Status:
For research use only (RUO)
Datasheet:
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Applications
DNA Hybridization
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Human lung adenocarcinoma (FFPE) stained with ALK Split FISH Probe. Arrows indicate ALK gene split.
Application Image
DNA Hybridization
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Gene Information
Entrez GeneID:
238
Gene Name:
ALK
Gene Alias:
CD246,Ki-1,TFG/ALK
Gene Description:
anaplastic lymphoma receptor tyrosine kinase
Omim ID:
105590
Gene Ontology:
Hyperlink
Gene Summary:
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3" half of ALK, derived from chromosome 2, is fused to the 5" portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
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