Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
Form:
Liquid
Quality Control Testing:
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product:
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction:
Store at 4°C in the dark.
Note:
Hybridization position of the probes on the chromosome.
Probe 1:Size:Fluorophore:Location:
CCND2Approximately 580kbTexas Red12p13.32
Probe 2:Size:Fluorophore:Location:
CCND2Approximately 690kbFITC12p13.32
Probe Gap:
The gap between two probes is approximately 90 kb
Origin:
Human
Source:
Genomic DNA
Notice:
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status:
For research use only (RUO)
Datasheet:
Download
Publication Reference
1.
Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B-cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall.Chuang WY, Chang H, Chang GJ, Wang TH, Chang YS, Wang TH, Yeh CJ, Ueng SH, Chien HP, Chang CY, Wan YL, Hsueh C.Histopathology. 2016 Dec 29. [Epub ahead of print]
Applications
Fluorescent In Situ Hybridization (Cell)
Protocol Download
Application Image
Fluorescent In Situ Hybridization (Cell)
Gene Information
Entrez GeneID:
894
Gene Name:
CCND2
Gene Alias:
KIAK0002,MGC102758
Gene Description:
cyclin D2
Omim ID:
123833
Gene Ontology:
Hyperlink
Gene Summary:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq
Other Designations:
G1/S-specific cyclin D2
Interactome
Gene Pathway
Cell cycle
Focal adhesion
Jak-STAT signaling pathway
p53 signaling pathway
Wnt signaling pathway
Related Disease
Breast cancer
Breast Neoplasms
Carcinoma, Hepatocellular
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Hepatitis B
Kidney Failure, Chronic
Liver Neoplasms
Narcolepsy
Neoplasm Invasiveness
Ovarian cancer
Ovarian Neoplasms
Related Product
DI0090
CCND2 & CDKN1A Protein Protein Interaction Antibody Pair
购物车为空，快去购物吧！
4000-520-616
咨询顾问
特别 提示
Download
