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Abnova/ALK Split FISH Probe/1kit/FS0001
  • Abnova/ALK Split FISH Probe/1kit/FS0001

Abnova/ALK Split FISH Probe/1kit/FS0001

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货号: FS0001
品牌: Abnova
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  • 详情
  • 使用说明
  • 常见问题
      • Specification
      • Gene Info
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
      • Form:
      • Liquid
      • Quality Control Testing:
      • Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.QC Testing of FS0001
      • Supplied Product:
      • DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
      • Storage Instruction:
      • Store at 4°C in the dark.
      • Note:
      • Hybridization position of the probes on the chromosome.
      • Probe 1:Size:Fluorophore:Location:
      • ALK(FITC)Approximately 770kbFITC2p23
      • Probe 2:Size:Fluorophore:Location:
      • ALK(Texas Red)Approximately 640kbTexas Red2p23
      • Probe Gap:
      • The gap between two probes is approximately 0 kb.
      • Origin:
      • Human
      • Source:
      • Genomic DNA
      • Notice:
      • We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
      • Regulation Status:
      • For research use only (RUO)
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Fluorescent In Situ Hybridization (Cell)
      • PDF DownloadProtocol Download
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)enlargeenlarge this image
      • Human lung adenocarcinoma (FFPE) stained with ALK Split FISH Probe. Human lung adenocarcinoma showed ALK gene split.
      • PDF DownloadProtocol Download
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)enlargeenlarge this image
      • Human anaplastic large cell lymphoma (FFPE) stained with ALK Split FISH Probe. Human anaplastic large cell lymphoma showed no ALK gene split.
      • PDF DownloadProtocol Download
      • Application Image
      • Fluorescent In Situ Hybridization (Cell)
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • Fluorescent <i>In Situ<i/> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 238
      • Gene Name:
      • ALK
      • Gene Alias:
      • CD246,Ki-1,TFG/ALK
      • Gene Description:
      • anaplastic lymphoma receptor tyrosine kinase
      • Omim ID:
      • 105590
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3" half of ALK, derived from chromosome 2, is fused to the 5" portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
      • Other Designations:
      • ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
      • Related Disease
      • Adenocarcinoma
      • Carcinoma, Non-Small-Cell Lung
      • Genetic Predisposition to Disease
      • Kidney Failure, Chronic
      • Lung Neoplasms
      • Multiple Sclerosis
      • Schizophrenia
      • Schizophrenia
      • Tobacco Use Disorder
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