Bilirubin Conjugate is a water soluble ditaurate derivative of bilirubin equivalent to bilirubin glucuronide derivatives. Bilirubin glucuronide derivatives are produced in vivo from the glucuronidation (addition of one or two glucuronic acids through a glycosidic bond) of bilirubin (also called indirect bilirubin) in a reaction catalyzed by the enzyme UDP Glucuronidase. The glucuronidation of bilirubin occurs in the liver to form the water soluble bilirubin mono or diglucuronide (also called bilirubin conjugate or direct bilirubin). Bilirubin conjugate is excreted from the liver in bile or is converted to urobilinogen and excreted in the urine as urobilin or in the feces as stercobilin.
References
1) Maghzal, G. J., M.-C. Leck, et al. (2009). “Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase.” Journal of Biological Chemistry 284(43): 29251-29259.2) MacLean, P. D., E. C. Drake, et al. (2007). “Bilirubin as an antioxidant in micelles and lipid bilayers: Its contribution to the total antioxidant capacity of human blood plasma.” Free Radical Biology and Medicine 43(4): 600.3) McCann, K. B., Y. Vucica, et al. (2009). “Effect of processing methods on colouration of human serum albumin preparations.” Biologicals 37(1): 32.4) Bulmer, A. C., K. Ried, et al. (2007). “The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test.” Mutation Research/Genetic Toxicology and Environmental Mutagenesis 629(2): 122.
| Categories | Biochemical Reagents |
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| Filter | HEME Pathway |
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| CAS Number | 68683-34-1 |
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| Molecular Formula | C37H44N6O10S2Na2 |
|---|
| Molecular Weight (g/mol) | 842.91 |
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| Purity | >70% |
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| Storage | -20 °C or below, protect from light |
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