Porphobilinogen is an intermediate in the heme synthesis pathway produced from d-Amino-levulinic acid in a reaction catalyzed by the enzyme ALA dehydrogenase. Porphobilinogen is converted to Hydroxylmethyl bilane in a reaction catalyzed by the enzyme Porphobilinogen Deaminase.
References
1) Roshal, M., J. Turgeon, et al. (2008). “Rapid Quantitative Method Using Spin Columns to Measure Porphobilinogen in Urine.” Clinical Chemistry 54(2): 429-431.2) Ford, R. E., M. J. Magera, et al. (2001). “Quantitative Measurement of Porphobilinogen in Urine by Stable-Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry.” Clinical Chemistry 47(9): 1627-1632.3) Strand, A., T. Asami, et al. (2003). “Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX.” Nature 421(6918): 79.4) Omata, Y., H. Sakamoto, et al. (2004). “Purification and Characterization of Human Uroporphyrinogen III Synthase Expressed in Escherichia coli.” Journal of Biochemistry 136(2): 211-220.
| Categories | Biochemical Reagents |
|---|
| Filter | HEME Pathway |
|---|
| CAS Number | 487-90-1 |
|---|
| Molecular Formula | C10H14N2O2 – H2O |
|---|
| Molecular Weight (g/mol) | 244.24 |
|---|
| Purity | >95% |
|---|
| Storage | -20 °C or below, protect from light |
|---|
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