Fluconazole is a fungistatic triazole antifungal targeting ergosterol synthesis leading to increased permeability of the fungal cell membrane.It is effective against Candida species, Cryptococcus species, neoformans, and dermatophytes.Fluconazole has been shown to down-regulate the metallothionein gene and inhibit CYP2C19, CYP2C9, and CYP3A4.
Fluconazole is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
Product SpecificationsFluconazole
MOLECULAR BIOLOGY GRADE
Formula: C13H12F2N6O
MW: 306.27 g/mol
Storage/Handling: Store at 4°C.This product is soluble in DMSO (5 mg/ml).
PubChem Chemical ID: 3365
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