SpeciesReactivity | |
EntrezGeneNumber | |
EntrezGeneSummary | ITAGVencodesintegrinalphachainV.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.TheI-domaincontainingintegrinalphaVundergoespost-translationalcleavagetoyielddisulfide-linkedheavyandlightchains,thatcombinewithmultipleintegrinbetachainstoformdifferentintegrins.Amongtheknownassociatingbetachains(betachains1,3,5,6,and8;"ITGB1","ITGB3","ITGB5","ITGB6",and"ITGB8"),eachcaninteractwithextracellularmatrixligands;thealphaVbeta3integrin,perhapsthemoststudiedofthese,isreferredtoastheVitronectinreceptor(VNR).Inadditiontoadhesion,manyintegrinsareknowntofacilitatesignaltransduction. |
GeneSymbol | - ITGAV
- CD51
- DKFZp686A08142
- VNRA
- MSK8
|
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P06756#Thealpha-Vintegrinsarereceptorsforvitronectin,cytotactin,fibronectin,fibrinogen,laminin,matrixmetalloproteinase-2,osteopontin,osteomodulin,prothrombin,thrombospondinandvonWillebrandfactor.TheyrecognizethesequenceR-G-Dinawidearrayofligands.IncaseofHIV-1infection,theinteractionwithextracellularviralTatproteinseemstoenhanceangiogenesisinKaposi"ssarcomalesions. SIZE:1048aminoacids;116038Da SUBUNIT:Heterodimerofanalphaandabetasubunit.Thealphasubunitiscomposedofanheavyandalightchainlinkedbyadisulfidebond.Alpha-Vassociateswitheitherbeta-1,beta-3,beta-5,beta-6orbeta-8subunit.InteractswithHIV-1Tat. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P06756##Belongstotheintegrinalphachainfamily.&Contains7FG-GAPrepeats. |