Store at 2-8°C in the dark. Please aliquot before use.
Note:
Hybridization position of the probes on the chromosome.
Probe:Fluorophore:Location:
ACTN4/CEN19pTexas Red/FITC19q13/19p13.11
Origin:
Human
Source:
Genomic DNA
Regulation Status:
Analyte Specific Reagent (ASR).Analytical and performance characteristics are not established.
Datasheet:
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Publication Reference
1.
Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.Nami Miura, Masahiro Kamita, Takanori Kakuya, Yutaka Fujiwara, Koji Tsuta, Hideaki Shiraishi, Fumitaka Takeshita, Takahiro Ochiya, Hirokazu Shoji, Wilber Huang, Yuichiro Ohe, Tesshi Yamada, Kazufumi Honda.Oncotarget. 2016 April 21.
2.
ACTN4 copy number increase as a predictive biomarker for chemoradiotherapy of locally advanced pancreatic cancer.Watanabe T, Ueno H, Watabe Y, Hiraoka N, Morizane C, Itami J, Okusaka T, Miura N, Kakizaki T, Kakuya T, Kamita M, Tsuchida A, Nagakawa Y, Wilber H, Yamada T, Honda KBr J Cancer. 2015 Feb 17;112(4):704-13. doi: 10.1038/bjc.2014.623. Epub 2015 Jan20.
3.
Copy number increase of ACTN4 is a prognostic indicator in salivary gland carcinoma.Watabe Y, Mori T, Yoshimoto S, Nomura T, Shibahara T, Yamada T, Honda KCancer Med. 2014 Feb 27. doi: 10.1002/cam4.214.
4.
Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.Noro R, Honda K, Tsuta K, Ishii G, Maeshima AM, Miura N, Furuta K, Shibata T, Tsuda H, Ochiai A, Sakuma T, Nishijima N, Gemma A, Asamura H, Nagai K, Yamada T.Ann Oncol. 2013 Jul 30.
Applications
DNA Hybridization
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Human lung adenocarcinoma (FFPE) stained with ACTN4 DNA Probe.
DNA Hybridization
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Human ovarian cancer (FFPE) stained with ACTN4 DNA Probe.
DNA Hybridization
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Human pancreatic cancer (FFPE) stained with ACTN4 DNA Probe.
Application Image
DNA Hybridization
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DNA Hybridization
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DNA Hybridization
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Gene Information
Entrez GeneID:
81
Gene Name:
ACTN4
Gene Alias:
ACTININ-4,DKFZp686K23158,FSGS,FSGS1
Gene Description:
actinin, alpha 4
Omim ID:
603278, 604638
Gene Ontology:
Hyperlink
Gene Summary:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
Other Designations:
actinin alpha4 isoform
Interactome
Gene Pathway
Adherens junction
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Systemic lupus erythematosus
Tight junction
Related Disease
Alport syndrome
Cardiovascular Diseases
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Edema
Genetic Predisposition to Disease
Glomerulosclerosis, Focal Segmental
Kidney Diseases
Proteinuria
Related Product
DF0002
ACTN4/CEN19p FISH Probe (Orange/Green)
DH0003
Anti-ACTN4 monoclonal antibody
DI0119
ACTN4 & CTNNB1 Protein Protein Interaction Antibody Pair