Echelon/BODIPY FL Phosphatidylinositol 4,5-bisphosphate/100 ug/C-45F6

BODIPY FL Phosphatidylinositol 4,5-bisphosphate is a water soluble analog of PI(4,5)P2 (PIP2) labeled with the green fluorophore, Bodipy^®-FL, at the sn-1 position.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.

Excitation/Emission

503/513 nm

Storage

-20 °C, protect from light

Publications

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1) Caromile, L. A., A. Oganesian, et al. (2010). “The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.” J Biol Chem 285(14): 10487-96.2)Rudge, S. A., D. M. Anderson, et al. (2004). “Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase.” Mol Biol Cell 15(1): 24-36.3) Oganesian, A., M. Poot, et al. (2003). “Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.” Proc Natl Acad Sci U S A 100(13): 7563-8.4) Omar-Hmeadi, M, Gandasi, N, Barg, S (2018). “PtdIns(4,5)P2 is not required for secretory granule docking” Traffic, DOI:10.1111/tra.12562

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