Wortmannin is a specific, irreversible inhibitor of phosphatidylinositol 3-kinases (IC50 ~ 2-3 nM). It shows similar potency for all classes of PI3Ks.
Publications
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1. Takahashi K, Tanaka T, Suzuki K. Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate. Cell Signal. 2010;22(3):510-8.