Immunogen | SyntheticpeptidefrommouseQKI-6. |
Host | Rabbit |
Specificity | QKI-6(QuakingProtein).Theantibodyrecognizesthe~38kDaprotein. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | QKIbelongstoafamilyofRNA-bindingproteinsthathaveanHNRNPK(MIM600712)homology(KH)domainembeddedina200-aminoacidregioncalledtheGSGdomain.OthermembersofthisfamilyincludeSAM68(KHDRBS1;MIM602489)andSF1(MIM601516)(ChenandRichard,1998[PubMed9671495]).[suppliedbyOMIM] |
GeneSymbol | - QKI
- DKFZp586I0923
- Hqk
- QK3
- QK
- HKQ
- HqkI
|
PurificationMethod | Serum |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q96PU8#RNA-bindingproteinthatplaysacentralroleinmyelinization.Bindstothe5"-NACUAAY-N(1,20)-UAAY-3"RNAcoresequence.Actsbyregulatingpre-mRNAsplicing,mRNAexport,mRNAstabilityandproteintranslation.RequiredtoprotectandpromotestabilityofmRNAssuchasMBPandCDKN1Bwhichpromotesoligodendrocytedifferentiation.ParticipatesinmRNAtransportbyregulatingthenuclearexportofMBPmRNA.AlsoinvolvedinregulationofmRNAsplicingofMAGpre-mRNA.Actsasatranslationalrepressor(Bysimilarity). SIZE:341aminoacids;37671Da SUBUNIT:Homodimer.DoesnotrequireRNAtohomodimerize.AbletoheterodimerizewithBICC1(Bysimilarity). SUBCELLULARLOCATION:Nucleus(Bysimilarity).Cytoplasm(Bysimilarity). TISSUESPECIFICITY:Expressedinthefrontalcortexofbrain. PTM:MethylatedbyPRMT1(Bysimilarity).&TyrosinephosphorylatedatitsC-terminus,probablybyFYN.PhosphorylationleadstodecreasedmRNA-bindingaffinity,affectingtransportand/orstabilizationofMBPmRNA(Bysimilarity). DISEASE:SwissProt:Q96PU8#Mayplayaroleingeneticsusceptibilitytoschizophrenia.QKIlevelsofsomeisoformssuchasisoform6,arefrequentlydown-regulatedinschizophrenicpatients.&DeletionoftheQKIgenemayplayaroleinastrocytictumors. SIMILARITY:SwissProt:Q96PU8##Contains1KHdomain. |